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Cluster Analysis of MR Imaging in Alzheimer’s Disease using Decision Tree Refinement

Ali Hamou, Andrew Simmons, Michael Bauer, Benoit Lewden, Yi Zhang, Lars-Olof Wahlund, Eric Westman, Megan Pritchard, Iwona Kloszewska, Patrizia Mecozzi, Hilkka Soininen, Magda Tsolaki, Bruno Vellas, Sebastian Muehlboeck, Alan Evans, Per Julin, Niclas Sjögren, Christian Spenger, Simon Lovestone, Femida Gwadry-Sridhar

Abstract



The use of novel analytical techniques (such as data clustering and decision trees) that can model and predict patient disease outcomes has great potential for assessing disease process and progression in Alzheimer’s disease and mild cognitive impairment. For this study, 124 different variables (generated from image data, demographics and data) have been compiled and analyzed using a modified clustering algorithm. Our aim was to determine the influence of these variables on the incidence of Alzheimer’s and mild cognitive impairment. Furthermore, we used a decision tree algorithm to model the level of “importance” of variants influencing this decision.

Keywords


Alzheimer's Disease, Mild Cognitive Impairment, Cluster Analysis, Decision Tree Analysis, MRI

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